Progress on the role of LIN28A/B in tumor development and progression

LIN28A and its homolog LIN28B are highly conserved RNA-binding proteins that play important roles in early embryonic development, somatic cell reprogramming, metabolism and tumorigenesis. LIN28A/B are highly expressed in a variety of malignant tumors such as breast cancer. They play important roles...

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Bibliographic Details
Published inYíchuán Vol. 46; no. 6; p. 452
Main Authors Yi-Wen, Zhang, Qin, Huang, Yan-Yun, Wu, Yue, Sun, Yong-Long, Wei
Format Journal Article
LanguageEnglish
Published China 20.06.2024
Subjects
Animals
Carcinogenesis - genetics
Disease Progression
Gene Expression Regulation, Neoplastic
Humans
MicroRNAs - genetics
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
RNA-Binding Proteins - genetics
RNA-Binding Proteins - metabolism
let-7 miRNA
tumor development and progression
LIN28B
LIN28A
therapeutic targets
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Summary:LIN28A and its homolog LIN28B are highly conserved RNA-binding proteins that play important roles in early embryonic development, somatic cell reprogramming, metabolism and tumorigenesis. LIN28A/B are highly expressed in a variety of malignant tumors such as breast cancer. They play important roles in the initiation, maintenance, and metastasis of tumors and are associated with poor prognosis. Previous studies have shown that the main regulatory mechanisms of LIN28A/B include let-7s dependent ways and let-7s independent ways, such as directly targeting mRNA. In this review, we summarize the function and molecular regulatory mechanisms of LIN28A/B in malignant tumors such as liver cancer, breast cancer and colorectal cancer, in order to provide references for further exploring the function and mechanism of LIN28A/B and their possible roles in clinical applications.
ISSN:0253-9772
DOI:10.16288/j.yczz.24-056