Influence of immunoregulatory cytokines (IL-2, IL-7 and IL-15) in vitro upon activation, proliferation and apoptosis of immune memory T-cells

Under the experimental conditions in vitro the effects of immunoregulatory cytokines (IL-2, IL-7 and IL-15) on the activation, proliferation and apoptosis of different subpopulations of immune memory T-cell (Cd45RO+) were investigated in healthy donors. It was demonstrated that the effects of rlL-2...

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Bibliographic Details
Published inT͡S︡itologii͡a Vol. 55; no. 8; p. 566
Main Authors Litvinova, L S, Sokhonevich, N A, Gutsol, A A, Kofanova, K A
Format Journal Article
LanguageRussian
Published Russia (Federation) 2013
Subjects
Adult
Apoptosis - drug effects
CD4-Positive T-Lymphocytes - cytology
CD4-Positive T-Lymphocytes - drug effects
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - cytology
CD8-Positive T-Lymphocytes - drug effects
CD8-Positive T-Lymphocytes - immunology
Cell Proliferation - drug effects
Dose-Response Relationship, Immunologic
Female
Humans
Immunologic Memory
Immunophenotyping
Interleukin-15 - pharmacology
Interleukin-2 - pharmacology
Interleukin-7 - pharmacology
Lymphocyte Activation - drug effects
Male
Primary Cell Culture
Recombinant Proteins - pharmacology
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Summary:Under the experimental conditions in vitro the effects of immunoregulatory cytokines (IL-2, IL-7 and IL-15) on the activation, proliferation and apoptosis of different subpopulations of immune memory T-cell (Cd45RO+) were investigated in healthy donors. It was demonstrated that the effects of rlL-2 in vitro equally affect the activation and proliferation of CD4+ and CD8+ subpopulations of memory T cells. It has been shown that high concentrations of rIL-2 lead to an increase in the number of CD8+ memory cells expressing apoptotic molecule CD95. Different effect of rIL-7 and rIL-15 on the activation and proliferation of cytotoxic CD8+ memory ells has been revealed in vitro. CD4+ memory lymphocytes have relative resistance to the activation and proliferative effect of rlL-7 and rlL-15, if compared with the effects of rIL-2, which can provide their relative resistance to the activation apoptosis as well as create the necessary conditions for the accelerated implementation of their functional capacity in the development of a secondary immune response.
ISSN:0041-3771