Lymphocyte receptors that regulate the immune-response--the key to the management of antitumor immunity

• Published in: Voprosy onkologij Vol. 61; no. 4; p. 523
• Main Authors: Kadagidze, Z G, Slavina, E G, Chertkova, A I
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2015
• Subjects: Animals; B7-H1 Antigen - immunology; Glucocorticoid-Induced TNFR-Related Protein - immunology; Humans; Lymphocytes - immunology; Neoplasms - immunology; Neoplasms - prevention & control; Programmed Cell Death 1 Receptor - immunology; Receptors, Immunologic - immunology; Receptors, OX40 - immunology
• ISSN: 0507-3758

Tumor uses various mechanisms to "escape" from immune surveillance including the important role of dysregulation of interaction of signals from corresponding co-stimulatory and co-inhibitory receptors (so-called "control points immunity"-- immune "checkpoints") modulating T-cell activation process. A creation of targeted drugs impacting on immune "checkpoints"" is a new promising trend in modern oncoimmunology. This review is devoted to a brief characterization of some receptors of immune competent cells (such as activation and inhibitor), which play a crucial role in the interaction of the immune system and tumors as well as targeted drugs acting on them for therapeutic purpose.