Lymphocyte receptors that regulate the immune-response--the key to the management of antitumor immunity

Tumor uses various mechanisms to "escape" from immune surveillance including the important role of dysregulation of interaction of signals from corresponding co-stimulatory and co-inhibitory receptors (so-called "control points immunity"-- immune "checkpoints") modulati...

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Bibliographic Details
Published inVoprosy onkologij Vol. 61; no. 4; p. 523
Main Authors Kadagidze, Z G, Slavina, E G, Chertkova, A I
Format Journal Article
LanguageRussian
Published Russia (Federation) 2015
Subjects
Animals
B7-H1 Antigen - immunology
Glucocorticoid-Induced TNFR-Related Protein - immunology
Humans
Lymphocytes - immunology
Neoplasms - immunology
Neoplasms - prevention & control
Programmed Cell Death 1 Receptor - immunology
Receptors, Immunologic - immunology
Receptors, OX40 - immunology
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Summary:Tumor uses various mechanisms to "escape" from immune surveillance including the important role of dysregulation of interaction of signals from corresponding co-stimulatory and co-inhibitory receptors (so-called "control points immunity"-- immune "checkpoints") modulating T-cell activation process. A creation of targeted drugs impacting on immune "checkpoints"" is a new promising trend in modern oncoimmunology. This review is devoted to a brief characterization of some receptors of immune competent cells (such as activation and inhibitor), which play a crucial role in the interaction of the immune system and tumors as well as targeted drugs acting on them for therapeutic purpose.
ISSN:0507-3758