Research progress in the relationship between gut microbiota metabolite trimethylamine N-oxide and ischemic stroke

• Published in: Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban Vol. 49; no. 3; p. 447
• Main Authors: Fu, Yu, Hou, Xiaoqian, Feng, Ziyun, Feng, Huiyue, Li, Li
• Format: Journal Article
• Language: Chinese; English
• Published: China 28.03.2024
• Subjects: Gastrointestinal Microbiome - physiology; Humans; Ischemic Stroke - metabolism; Methylamines - blood; Methylamines - metabolism; Risk Factors; trimethylamine N-oxide; gut microbiota; ischemic stroke
• ISSN: 1672-7347
• DOI: 10.11817/j.issn.1672-7347.2024.230427

Ischemic stroke (IS) is a severe cerebrovascular disease that seriously endangers human health. Gut microbiota plays a key role as an intermediate mediator in bidirectional regulation between the brain and the intestine. In recent years, trimethylamine N-oxide (TMAO) as a gut microbiota metabolite has received widespread attention in cardiovascular diseases. Elevated levels of TMAO may increase the risk of IS by affecting IS risk factors such as atherosclerosis, atrial fibrillation, hypertension, and type 2 diabetes. TMAO exacerbates neurological damage in IS patients, increases the risk of IS recurrence, and is an independent predictor of post-stroke cognitive impairment (PSCI) in patients. Current research suggests that the mechanisms of TMAO action include endothelial dysfunction, promoting of foam cell formation, influence on cholesterol metabolism, and enhancement of platelet reactivity. Lowering plasma TMAO levels through the rational use of traditional Chinese medicine, dietary management, vitamins, and probiotics can prevent and treat IS.