Effect of IL-1beta on growth properties of vaginal microsymbionts

Study the effect of IL-1beta in concentrations that are characteristic for vaginal normo- and pathocenosis on growth properties of vaginal microsymbionts. Concentration of IL-1beta in vaginal contents of women during bacterial vaginosis and normocenosis was determined by using enzume immunoassay. Ch...

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Bibliographic Details
Published inŽurnal mikrobiologii, ėpidemiologii i immunobiologii no. 4; p. 65
Main Authors Kremleva, E A, Bukharin, O V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.2013
Subjects
Adult
Biofilms - drug effects
Biofilms - growth & development
Culture Media, Conditioned
Escherichia coli - drug effects
Escherichia coli - growth & development
Female
Humans
Interleukin-1beta - administration & dosage
Lactobacillus - drug effects
Lactobacillus - growth & development
Staphylococcus aureus - drug effects
Staphylococcus aureus - growth & development
Vagina - drug effects
Vagina - microbiology
Vaginosis, Bacterial - drug therapy
Vaginosis, Bacterial - microbiology
Vaginosis, Bacterial - pathology
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Summary:Study the effect of IL-1beta in concentrations that are characteristic for vaginal normo- and pathocenosis on growth properties of vaginal microsymbionts. Concentration of IL-1beta in vaginal contents of women during bacterial vaginosis and normocenosis was determined by using enzume immunoassay. Changes of growth characteristics and biofilm formation ability of Staphylococcus aureus, Escherichia coli, Lactobacilus spp., Corynebacterium spp. under the effect of various IL-1beta concentrations by method of O'Toole G.A. (1999) were studied. IL-1beta in concentrations characteristic for normocenosis was shown to be able to cause stimulating effect on growth properties of lactobacilli and corynebacteria and suppress growth of S. aureus and E. coli in both plankton and biofilm cultures. IL-1beta concentrations characteristic for vaginal dysbiosis on the contrary result in suppression of growth of lactobacilli biomass against the background of stimulation of growth properties and biofilm formation ability of S. aureus and E. coli. Differential dose-dependent effect of IL-1beta on biomass growth and biofilm formation ability of vaginal microsymbionts is a mechanism of regulation of vaginal microbiocenosis.
ISSN:0372-9311