NHE3 activity and trafficking depend on the state of actin organization in proximal tubule

The present study was addressed to define the contribution of cytoskeleton elements in the kidney proximal tubule Na+/H+ exchanger 3 (NHE3) activity under basal conditions. We used luminal membrane vesicles (LMV) isolated from suspensions of rat cortical tubules pretreated with either colchicine (Co...

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Bibliographic Details
Published inAmerican journal of physiology. Renal physiology Vol. 49; no. 2; pp. F283 - F290
Main Authors CHALUMEAU, C, DU CHEYRON, D, DEFONTAINE, N, KELLERMANN, O, PAILLARD, M, POGGIOLI, J
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.02.2001
Subjects
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Hydrogen
Kidneys
Medical research
Plasma
Proteins
Sodium
Vertebrates: urinary system
Molecular arrangement
Cation exchange
Intracellular transport
Rodentia
Kidney
Protein
Vertebrata
Mammalia
Urinary system
Mouse
Actin
Animal
Sodium ion
Cytoskeleton
Hydrogen ion
Proximal tube
Cation exchanger
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Summary:The present study was addressed to define the contribution of cytoskeleton elements in the kidney proximal tubule Na+/H+ exchanger 3 (NHE3) activity under basal conditions. We used luminal membrane vesicles (LMV) isolated from suspensions of rat cortical tubules pretreated with either colchicine (Colch) or cytochalasin D (Cyto D).
ISSN:1931-857X
1522-1466