Epidemiological analysis of cytogenetic abnormalities in patients with newly-diagnosed multiple myeloma: a multi-center retrospective study

• Published in: Zhōnghuá xuèyèxué zázhì Vol. 41; no. 1; p. 10
• Main Authors: Yuan, R F, Dong, Y J, Li, C R, Huang, W R, Zhang, L M, Zhu, Q, Xu, L, Xu, Y J, Xu, Q, Gao, G X, Jin, F Y
• Format: Journal Article
• Language: Chinese
• Published: China 14.01.2020
• Subjects: Chromosome Aberrations; Cytogenetic Analysis; Humans; In Situ Hybridization, Fluorescence; Multiple Myeloma; Prognosis; Retrospective Studies; High risk; Cytogenetic abnormality; Double-hit; Epidemiology; Multiple myeloma
• ISSN: 0253-2727
• DOI: 10.3760/cma.j.issn.0253-2727.2020.01.003

To analyze the frequency and composition of risk-related cytogenetic abnormalities (CAs) in patients with newly-diagnosed multiple myeloma (NDMM) . The frequency and composition of risk-related CAs from a cohort of 1 015 Chinese patients with NDMM were determined by interphase fluorescence in situ hybridization (iFISH) , individually or in combination. Of the cohort of 1 015 Chinese patients with NDMM, the frequencies of IgH arrangement, del (13q) /13q14, 1q gain and del (17p) were 54.0%, 46.4%, 46.1% (35.8% and 12. 7% for 3 or more than 3 copies) and 9.9%, respectively. Among 454 patients who had the baseline information for all risk-related CAs [except t (14;20) , which was not covered by the FISH panels performed routinely at all five centers], the frequencies of t (4;14) , t (11;14) or t (14;20) were 14.1%, 11.2% and 4.8%, respectively; of them, 44.3% patients carried 2 or more CAs (28.0%, 13.4% and 2.9% for 2, 3 or ≥4 CAs) ; 83.3%, 95.0% or 68.6% patients with 1q gain, del (17p) or IgH rearrangement had