Ca2+ sensitivity of BK channels in GH3 cells involves cytosolic phospholipase A2

To test the hypothesis that intracellular Ca2+ activation of large-conductance Ca2+-activated K+ (BK) channels involves the cytosolic form of phospholipase A2 (cPLA2), we first inhibited the expression of cPLA2 by treating GH3 cells with antisense oligonucleotides directed at the two possible transl...

Full description

Saved in:
Bibliographic Details
Published inAmerican Journal of Physiology: Cell Physiology Vol. 45; no. 1; pp. C201 - C209
Main Authors DENSON, D. D, WORRELL, R. T, MIDDLETON, P, EATON, D. C
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 1999
Subjects
Anatomy & physiology
Biological and medical sciences
Calcium
Cell membranes. Ionic channels. Membrane pores
Cell structures and functions
Cells
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
Potassium
Rat
Enzyme
Biological transport
Rodentia
Electrophysiology
Ion transport
Esterases
Ionic channel
Calcium Ions
Phospholipase A
Potassium Ions
Carboxylic ester hydrolases
Vertebrata
Regulation(control)
Cell line
Mammalia
Hydrolases
Pituitary gland
Ionic conductance
Mechanism of action
Online AccessGet full text

Cover

More Information
Summary:To test the hypothesis that intracellular Ca2+ activation of large-conductance Ca2+-activated K+ (BK) channels involves the cytosolic form of phospholipase A2 (cPLA2), we first inhibited the expression of cPLA2 by treating GH3 cells with antisense oligonucleotides directed at the two possible translation start sites on cPLA2.
ISSN:0363-6143
1522-1563