ACE inhibition and ANG II receptor blockade improve glomerular size-selectivity in IgA nephropathy

• Published in: American journal of physiology. Renal physiology Vol. 45; no. 3; pp. F457 - FF466
• Main Authors: REMUZZI, A, PERICO, N, SANGALLI, F, VENDRAMIN, G, MORIGGI, M, RUGGENENTI, P, REMUZZI, G
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Physiological Society 01.03.1999
• Subjects: Anatomy & physiology; Antihypertensive agents; Biological and medical sciences; Cardiovascular system; Kidneys; Medical sciences; Pharmacology. Drug treatments; Kidney disease; Human; Glomerulonephritis; Immunopathology; IgA; Urinary system disease; Glomerular filtration; Renal function; Selectivity; Molecular size; Clearance; Kidney; Urinary system; Enalapril; Irbesartan; Peptidergic receptor; Blood pressure; Hemodynamics; Angiotensin antagonist; ACE inhibitor; Proteinuria

Protein trafficking across the glomerular capillary has a pathogenic role in subsequent renal damage. Despite evidence that angiotensin-converting enzyme (ACE) inhibitors improve glomerular size-selectivity, whether this effect is solely due to ANG II blocking or if other mediators also play a contr...