Gender-dependent expression of ERalpha in arsenic exposed mice offspring's lung tissue

To observe theexpression variations of estrogen receptor alpha (ERalpha) in different periods of mice offspring and the gender-dependent differences in the lung tissue with parental arsenic exposure. Parental female mice were exposed to arsenic by gavage from gestational day 8th to offspring infancy...

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Published inSichuan da xue xue bao. Journal of Sichuan University. Yi xue ban Vol. 46; no. 2; p. 197
Main Authors Shi, Meng-meng, Chen, Guo-jian, Zhang, Yang, Che, Wang-jun, Zhang, Hao
Format Journal Article
LanguageChinese
Published China 01.03.2015
Subjects
Animals
Arsenic - toxicity
Arsenites - toxicity
Estrogen Receptor alpha - metabolism
Female
Lung - drug effects
Lung - metabolism
Male
Maternal Exposure
Mice
Pregnancy
RNA, Messenger
Sex Factors
Sodium Compounds - toxicity
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Summary:To observe theexpression variations of estrogen receptor alpha (ERalpha) in different periods of mice offspring and the gender-dependent differences in the lung tissue with parental arsenic exposure. Parental female mice were exposed to arsenic by gavage from gestational day 8th to offspring infancy, and offspring were exposed to arsenic by drinking water after infancy. The expression level of ERalpha mRNA and protein in lung tissue of the male and female offspring in different developmental periods and different doses (low, middle, high) of sodium arsenite exposure were detected by real-time PCR and Western blot. ERalpha mRNA expression in female lung tissue was lower than male in embryonic period (P<0.05); ERalpha mRNA expression in female lung tissue was higher than that of male in infant and adult periods (middle dose of infancy P<0.05, middle and high doses of adulthood P<0.05); No statistical significances were observed in embryo, infancy and adulthood control groups. ERalpha mRNA expression in female l
ISSN:1672-173X