Susceptibility status of Anopheles gambiae sensu lato to insecticides commonly used for malaria control in Mali

• Published in: Bulletin de la Societe de pathologie exotique (1990) Vol. 109; no. 1; pp. 39 - 45
• Main Authors: Keïta, M, Traoré, S, Sogoba, N, Dicko, A M, Coulibaly, B, Sacko, A, Doumbia, S, Traoré, S F
• Format: Journal Article
• Language: French
• Published: France 01.02.2016
• Subjects: Animals; Anopheles - drug effects; Anopheles - growth & development; Drug Evaluation, Preclinical; Female; Humans; Insect Vectors - drug effects; Insect Vectors - growth & development; Insecticide Resistance; Insecticides - pharmacology; Malaria - prevention & control; Malaria - transmission; Mali - epidemiology; Mosquito Control - methods; Mosquito Control - standards; Resistance; Permethrin; DDT; Mali; Lambda-cyhalothrin; Fenitrothion; Insecticides; Malaria vectors; Sensibility; Bendiocarb; Deltamethrin; Sub-Saharan Africa
• ISSN: 0037-9085; 1961-9049
• DOI: 10.1007/s13149-015-0461-2

The objective of this work was to monitor the susceptibility of malaria vectors to insecticides in nine sentinel sites of the National Malaria Control Program in Mali. The study was performed during the rainy seasons of 2010 and 2011. WHO bioassays were conducted using F0 and/or F1 from wild collected females. The insecticides used were lambda-cyhalothrin 0.05%, DDT 4%, permethrin 0.75%, deltamethrin 0.05%, bendiocarb 0.1% and fenitrothion 1.0%. Results showed suspicion of resistance to pyrethroids and organochlorine in An. gambiae s.l. at almost all the sites except Yanfolila where the vector was susceptible to lambda-cyhalothrin (98.0%) [CI 95%, 98-99.8] and to DDT (100%). An. gambiae s.l. was susceptible to bendiocarb in five of the sites (Gao, Bougouni, Djenné, Yanfolila, Tombouctou) while there was a suspicion of resistance at the other sites (Kati, Niono, Bandiagara, Kita). Fenitrothion remains efficient except in the rice area of Niono, where there was a suspicion of resistance with a mortality rate of 92% [IC 95% 88.3-94.8]. Thus, it could be used as an alternative insecticide for IRS in Mali. These results show resistance to pyrethroids, the main insecticide family used in public health (and to some extent in agriculture). This could compromise the malaria vector control efforts in Mali where pyrethroids are used for both in bed nets and in IRS.