Study on mechanism of enhancing antioxidant activity in fermented Ziziphi Spinosae Semen with Poria cocos

In this study, the antioxidant property changes in fermented Ziziphi Spinosae Semen(FZSS) with Poria cocos were analyzed by DPPH, ABTS and FRAP methods. Then the content determination of active ingredients and ~1H nuclear magnetic resonance(~1H-NMR) spectroscopy were also used to investigate the mec...

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Bibliographic Details
Published inZhongguo zhongyao zazhi Vol. 46; no. 3; p. 620
Main Authors Li, Ze, Xie, Yu-Jun, Duan, Hui-Zhu, Cui, Xiao-Fang, Pei, Xiang-Ping, Yan, Yan, DU, Chen-Hui
Format Journal Article
LanguageChinese
Published China 01.02.2021
Subjects
Antioxidants
Chromatography, High Pressure Liquid
Drugs, Chinese Herbal
Poria
Semen
Wolfiporia
Ziziphus
1H-NMR metabonomics
fermentation
antioxidant
Ziziphi Spinosae Semen
Poria cocos
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Summary:In this study, the antioxidant property changes in fermented Ziziphi Spinosae Semen(FZSS) with Poria cocos were analyzed by DPPH, ABTS and FRAP methods. Then the content determination of active ingredients and ~1H nuclear magnetic resonance(~1H-NMR) spectroscopy were also used to investigate the mechanism of FZSS with P. cocos in enhancing the antioxidant activity. The results showed that the content of active ingredients such as total phenols, total saponins and total polysaccharides were significantly increased during the fermentation time. The results of ~1H-NMR metabonomics showed that the contents of amino acids such as leucine, lysine, valine and alanine, nitrogen compounds such as creatine, creatinine, and betaine, and secondary metabolites, for instance, jujuboside A and spinosin were higher after fermentation, and above components showed positive correlation with antioxidant capacity in Pearson correlation analysis. Therefore, it was inferred that the enhancement of antioxidant activity of FZSS may b
ISSN:1001-5302
DOI:10.19540/j.cnki.cjcmm.20201012.202