Chronic sleep deprivation exacerbates cognitive and pathological impairments in APP/PS1/tau triple transgenic Alzheimer's disease model mice

Sleep exerts important functions in the regulation of cognition and emotion. Recent studies have found that sleep disorder is one of the important risk factors for Alzheimer's disease (AD), but the effects of chronic sleep deprivation on the cognitive functions of AD model mice and its possible...

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Published inSheng li hsüeh pao Vol. 73; no. 3; p. 471
Main Authors Wang, Chun, Cao, Xu, Yin, Jing, Gao, Wen-Rui, Li, Wei-Ran, Qi, Jin-Shun, Wu, Mei-Na
Format Journal Article
LanguageChinese
Published China 25.06.2021
Subjects
Alzheimer Disease
Amyloid beta-Peptides
Amyloid beta-Protein Precursor - genetics
Animals
Cognition
Disease Models, Animal
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Presenilin-1
Sleep Deprivation
tau Proteins
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Summary:Sleep exerts important functions in the regulation of cognition and emotion. Recent studies have found that sleep disorder is one of the important risk factors for Alzheimer's disease (AD), but the effects of chronic sleep deprivation on the cognitive functions of AD model mice and its possible mechanism are still unclear. In the present study, 8-month-old male APP/PS1/tau triple transgenic AD model (3xTg-AD) mice and wild type (WT) mice (n = 8 for each group) were subjected to chronic sleep deprivation by using the modified multiple platform method, with 20 h of sleep deprivation each day for 21 days. Then, open field test, elevated plus maze test, sugar water preference test, object recognition test, Y maze test and conditioned fear memory test were performed to evaluate anxiety- and depression-like behaviors, and multiple cognitive functions. In addition, the immunohistochemistry technique was used to observe pathological characteristics in the hippocampus of mice. The results showed that: (1) Chronic slee
ISSN:0371-0874