No Association of the - 141C Ins/Del Polymorphism of the Dopamine D2 Receptor with Schizophrenia

Recently, a putative functional polymorphism (- 141C Ins/Del) in the 5'-flanking region of the dopamine D (2) receptor was found. An association of the Ins allele with schizophrenia has been described in a Japanese sample. In the present study this association was examined in a German schizophr...

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Published inPsychiatrische Praxis Vol. 30; no. Suppl 2; p. 212
Main Authors Rohrmeier, Thomas, Putzhammer, Albert, Sartor, Heino, Knapp, Michael, Albus, Margot, Borrmann-Hassenbach, Margitta, Lichtermann, Dirk, Wildenauer, Dieter, Schwab, Sibylle, Maier, Wolfgang, Klein, Helmfried E., Eichhammer, Peter
Format Journal Article
LanguageGerman
Published Germany 01.05.2003
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Summary:Recently, a putative functional polymorphism (- 141C Ins/Del) in the 5'-flanking region of the dopamine D (2) receptor was found. An association of the Ins allele with schizophrenia has been described in a Japanese sample. In the present study this association was examined in a German schizophrenia patient population. In a family based approach 190 German family trios were analyzed for the - 141C Ins/Del genotype. Using the transmission disequilibrium test (TDT) we found no evidence for an association of the Ins allele with schizophrenia (TDT = 0.152, P = 0.696). In parallel, we performed an independent case control study with 268 schizophrenic patients and 244 controls. Again, we did not detect an overrepresentation of the Ins allele in patients (P = 0.124). Thus, our data do not support the hypothesis that the - 141C Ins variant plays a major role in predisposition to schizophrenia. To confirm our conclusion further preferentially family based studies are needed.
ISSN:1439-0876