Current possibilities of diagnostics and treatment of immunological causes of female infertility

The immune system plays an important role in many processes of human reproduction. During pregnancy, mother's body has to accept the semialogenic fetus, therefore the role of immune processes has a high importance. Tolerance of the fetus by the mother's immune system is ensured by a comple...

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Published inČasopis lékařů českých Vol. 160; no. 1; p. 5
Main Authors Malíčková, Karin, Ambrusová, Zuzana, Belvončíková, Slávka, Bergendiová, Katarína, Krátká, Zuzana, Lešťan, Martin, Luxová, Štěpánka, Novák, Jiří, Tibenská, Elena, Vydláková, Jana, Sedláčková, Lenka
Format Journal Article
LanguageEnglish
Published Czech Republic 2021
Subjects
Embryo Implantation
Female
Humans
Immune System
Infertility, Female - diagnosis
Infertility, Female - etiology
Infertility, Female - therapy
Pregnancy
Pregnancy Complications
Premature Birth
immunomodulation
NK cells
Autoantibodies
abortion
cellular immunity
in vitro fertilization
Miscarriage
infertility
Immunity
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Summary:The immune system plays an important role in many processes of human reproduction. During pregnancy, mother's body has to accept the semialogenic fetus, therefore the role of immune processes has a high importance. Tolerance of the fetus by the mother's immune system is ensured by a complex of immune mechanisms, the knowledge of which brings us to the new insights into human reproduction processes and in seeking of new ways to modulate immunity in repeated embryo implantation failures, miscarriages, premature births, preeclampsia, and other fertility disorders and pregnancy complications. The review article is a summary of current possibilities of immunological laboratory diagnostics in reproductive immunology, presents indications for these tests and their interpretation, and mentions possible methods of therapeutic immune intervention.
ISSN:0008-7335