Detection of cancer stem cells in ovarian cancer

• Published in: Ceská gynekologie Vol. 79; no. 1; p. 7
• Main Authors: Bartáková, A, Pecková, K, Daum, O, Bouda, J
• Format: Journal Article
• Language: Czech
• Published: Czech Republic 01.01.2014
• Subjects: AC133 Antigen; Adult; Antigens, CD - metabolism; Biomarkers, Tumor - metabolism; Carcinoma, Ovarian Epithelial; Female; Glycoproteins - metabolism; Humans; Hyaluronan Receptors - metabolism; Middle Aged; Neoplasms, Glandular and Epithelial - diagnosis; Neoplasms, Glandular and Epithelial - immunology; Neoplasms, Glandular and Epithelial - metabolism; Neoplastic Stem Cells - immunology; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Ovarian Neoplasms - diagnosis; Ovarian Neoplasms - immunology; Ovarian Neoplasms - metabolism; Peptides - metabolism
• ISSN: 1210-7832

Detection of cancer stem cells (CSCs) in ovarian cancer, influence of CSCs on overall survival, disease free interval. Results in comparison with literature. Original study. Department of Gynaecology and Obstetrics, Faculty Hospital Pilsen and Medical Faculty in Pilsen, Charles University, Šikls Institute of Pathology, Faculty Hospital Pilsen and Medical Faculty in Pilsen, Charles University. 23 specimens of papillary-serous ovarian carcinoma and 4 specimens of endometroid ovarian carcinoma were included in the study. Specific antibodies to CD44 and CD133 antigens were used. Immunoreaction of both CD44 and CD133 was evaluated for the high power field. There was no significant correlation between CD44 expression and disease free interval and overall survival. CD133 expression was not evaluated due to an inadequate immunoreaction antibody - antigene. We did not find any statistically correlation between CD44 expression and overall survival and disease free interval in our series of patients with ovarian carcinoma. It seems to be better to use different antibody for CD133 detection.