Analysis of epidemiological characteristics of drug induced liver injury associated with Baixianpi Preparations

• Published in: Zhongguo zhongyao zazhi Vol. 44; no. 5; p. 1048
• Main Authors: Ge, Fei-Lin, Niu, Ming, Han, Zi-Xin, Zhang, Yan-Fang, Wang, Jia-Bo, Xiao, Xiao-He, Guo, Yu-Ming, Cao, Jun-Ling
• Format: Journal Article
• Language: Chinese
• Published: China 01.03.2019
• Subjects: epidemiological characteristics; drug induced liver injury; the rational use of drugs; Baixianpi Preparations
• ISSN: 1001-5302
• DOI: 10.19540/j.cnki.cjcmm.20181217.001

A retrospective study was performed in drug-induced liver injury(DILI) cases associated with Dictamni Cortex(Baixianpi,BXP) Preparations,which were treated at grade Ⅲ class A liver disease hospitals from 2008 to 2016 and spontaneously reported for adverse reactions between 2012 and 2016 at HILI Cloud(hilicloud.net). The results showed 25 DLII cases associated with BXP Preparations treated at grade Ⅲ class A liver disease hospitals during the 9 years,including only 14 cases in line with the clinical diagnostic criteria of Guidelines for the Diagnosis and Treatment of Herb-Induced Liver Injury. And 74 DILI cases associated with BXP Preparations spontaneously reports adverse reactions,and 18. 92% of them had unreasonable medication,including polypharmacy(21. 43%),overdose(28. 57%) and repeated dosage(50%). And 47 DILI cases used BXP Preparations to treat psoriasis and vitiligo(a total of59. 57%). The time range of taking BXP Preparations until liver injury occurred was 1-366 d,with the median of 18 d. The dose o