Effects of growth hormone and IGF-I on cardiac hypertrophy and gene expression in mice

Cardiac hypertrophic and contractile responses were studied in mice administered growth hormone (GH) and insulin-like growth factor (IGF-I) (8 mg x kg-1 x day-1), alone or in combination (IGF-I/ GH), for 2 wk. Also, changes in expression of selected left ventricular (LV) genes in response to IGF-I/G...

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Published inAmerican journal of physiology. Heart and circulatory physiology Vol. 44; no. 2; pp. H393 - H399
Main Authors TANAKA, N, RYOKE, T, HONGO, M, MAO, L, ROCKMAN, H. A, CLARK, R. G, ROSS, J. JR
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.08.1998
Subjects
Biological and medical sciences
Cell physiology
Fundamental and applied biological sciences. Psychology
Genes
Heart
Hormones
Molecular and cellular biology
Peptides
Physical growth
Responses to growth factors, tumor promotors, other factors
Ribonucleic acid
RNA
Heart
STH
Rodentia
Contractility
Cardiovascular disease
Heart ventricle
Atrial natriuretic peptide
Gene expression
Insulin like growth factor 1
Vertebrata
Natriuretic hormone
Mammalia
Adenohypophyseal hormone
Mouse
Heart disease
Blood pressure
Circulatory system
Hemodynamics
Hypertrophy
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Summary:Cardiac hypertrophic and contractile responses were studied in mice administered growth hormone (GH) and insulin-like growth factor (IGF-I) (8 mg x kg-1 x day-1), alone or in combination (IGF-I/ GH), for 2 wk. Also, changes in expression of selected left ventricular (LV) genes in response to IGF-I/GH were compared with those in other forms of cardiac hypertrophy.
ISSN:0363-6135
1522-1539