The effects of pregnancy and lactation on bone and mineral metabolism.
To meet the fetus's calcium demand in the 3rd trimester as much as 300~500 mg/day, intestinal calcium absorption in pregnant women is upregulated, without comparable increase in bone resorption. On the contrary, to provide 210 mg/day of calcium for the neonate, bone resorption by osteoclasts an...
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| Published in | Clinical calcium Vol. 29; no. 1; p. 35 |
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| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japan
2019
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| Online Access | Get more information |
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| Summary: | To meet the fetus's calcium demand in the 3rd trimester as much as 300~500 mg/day, intestinal calcium absorption in pregnant women is upregulated, without comparable increase in bone resorption. On the contrary, to provide 210 mg/day of calcium for the neonate, bone resorption by osteoclasts and osteocytes is markedly upregulated in maternal skeleton caused by low estrogen and high PTHrP as a consequence of elevated prolactin production, without any increase in intestinal calcium absorption. Breastfeeding women lose 5~10%of trabecular bone during 3 to 6 months of lactation. |
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| ISSN: | 0917-5857 |