Heterologous biomimetic synthesis of active ingredients in traditional Chinese medicine:a new mode for protection and development of traditional Chinese medicine resources

• Published in: Zhongguo zhongyao zazhi Vol. 48; no. 9; p. 2284
• Main Authors: Wang, Jie, Dai, Zhu-Bo
• Format: Journal Article
• Language: Chinese
• Published: China 01.05.2023
• Subjects: synthetic biology; traditional Chinese medicine resources; biomimetic synthesis; active ingredients in traditional Chinese medicine
• ISSN: 1001-5302
• DOI: 10.19540/j.cnki.cjcmm.20230308.101

Heterologous biomimetic synthesis of the active ingredients of traditional Chinese medicine(TCM) is a new mode of resource acquisition and has shown great potential in the protection and development of TCM resources. According to synthetic biology and by constructing biomimetic microbial cells and imitating the synthesis of active ingredients in medicinal plants and animals, the key enzymes obtained from medicinal plants and animals are scientifically designed and systematically reconstructed and optimized to realize the heterologous synthesis of the active ingredients in microorganisms. This method ensures an efficient and green acquisition of target products, and also achieves large-scale industrial production, which is conducive to the production of scarce TCM resources. Additiona-lly, the method playes a role in agricultural industrialization, and provides a new option for promoting the green and sustainable deve-lopment of TCM resources. This review systematically summarized the important progress in the