The expression of PIK3CA in nasopharyngeal carcinoma

• Published in: Lin chuang er bi yan hou ke za zhi Vol. 31; no. 9; p. 687
• Main Authors: Yao, X, Zhang, J J, Han, L, Pang, R
• Format: Journal Article
• Language: Chinese
• Published: China 05.05.2017
• Subjects: Carcinoma - metabolism; Class I Phosphatidylinositol 3-Kinases - metabolism; Humans; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms - metabolism; Phosphatidylinositol 3-Kinases; Prognosis; Survival Analysis; serine threonine kinase; phosphatidyl inositol 3- kinase; nasopharyngeal carcinoma
• ISSN: 1001-1781
• DOI: 10.13201/j.issn.1001-1781.2017.09.009

Analysis of phosphatidyl inositol 3-kinase catalytic subunit of alpha(PIK3CA) expression in nasopharyngeal carcinoma and prognosis. On normal nasopharyngeal mucosa and tissue adjacent to carcinoma and nasopharyngeal carcinoma tissues serine/threonine protein kinase (pAkt) and the expression of PIK3CA status detection,immunohistochemical method,in-depth analysis is made to the relationship between the development of tumor; The expression of tumour stage,prognosis and IK3CA comprehensive analysis of the relationship between. Tissue adjacent to carcinoma,pAkt in nasopharyngeal carcinoma tissue,the expression of PIK3CA increased significantly( <0.05). There was a significant correlation between the degree of overexpression of PIK3CA and clinical stage(T stage: =0.437, <0.01;N stage: =0.318, <0.05; clinical stage: =0.496, <0.01).Compared with PIK3CA-negative patients,PIK3CA-positive patients had a worse overall survival( <0.01). PIK3CA is highly expressed in nasopharyngeal carcinoma,which is significantly associat