Highly magnetic iron carbide nanoparticles as effective T(2) contrast agents
This paper reports that iron carbide nanoparticles with high air-stability and strong saturation magnetization can serve as effective T2 contrast agents for magnetic resonance imaging. Fe5C2 nanoparticles (~20 nm in diameter) exhibit strong contrast enhancement with an r2 value of 283.2 mM(-1) S(-1)...
Saved in:
| Published in | Nanoscale Vol. 6; no. 2; p. 726 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
21.01.2014
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 2040-3372 2040-3372 |
| DOI | 10.1039/c3nr04691e |
Cover
| Abstract | This paper reports that iron carbide nanoparticles with high air-stability and strong saturation magnetization can serve as effective T2 contrast agents for magnetic resonance imaging. Fe5C2 nanoparticles (~20 nm in diameter) exhibit strong contrast enhancement with an r2 value of 283.2 mM(-1) S(-1), which is about twice as high as that of spherical Fe3O4 nanoparticles (~140.9 mM(-1) S(-1)). In vivo experiments demonstrate that Fe5C2 nanoparticles are able to produce much more significant MRI contrast enhancement than conventional Fe3O4 nanoparticles in living subjects, which holds great promise in biomedical applications. |
|---|---|
| AbstractList | This paper reports that iron carbide nanoparticles with high air-stability and strong saturation magnetization can serve as effective T2 contrast agents for magnetic resonance imaging. Fe5C2 nanoparticles (~20 nm in diameter) exhibit strong contrast enhancement with an r2 value of 283.2 mM(-1) S(-1), which is about twice as high as that of spherical Fe3O4 nanoparticles (~140.9 mM(-1) S(-1)). In vivo experiments demonstrate that Fe5C2 nanoparticles are able to produce much more significant MRI contrast enhancement than conventional Fe3O4 nanoparticles in living subjects, which holds great promise in biomedical applications. This paper reports that iron carbide nanoparticles with high air-stability and strong saturation magnetization can serve as effective T2 contrast agents for magnetic resonance imaging. Fe5C2 nanoparticles (~20 nm in diameter) exhibit strong contrast enhancement with an r2 value of 283.2 mM(-1) S(-1), which is about twice as high as that of spherical Fe3O4 nanoparticles (~140.9 mM(-1) S(-1)). In vivo experiments demonstrate that Fe5C2 nanoparticles are able to produce much more significant MRI contrast enhancement than conventional Fe3O4 nanoparticles in living subjects, which holds great promise in biomedical applications.This paper reports that iron carbide nanoparticles with high air-stability and strong saturation magnetization can serve as effective T2 contrast agents for magnetic resonance imaging. Fe5C2 nanoparticles (~20 nm in diameter) exhibit strong contrast enhancement with an r2 value of 283.2 mM(-1) S(-1), which is about twice as high as that of spherical Fe3O4 nanoparticles (~140.9 mM(-1) S(-1)). In vivo experiments demonstrate that Fe5C2 nanoparticles are able to produce much more significant MRI contrast enhancement than conventional Fe3O4 nanoparticles in living subjects, which holds great promise in biomedical applications. |
| Author | Hu, Juan Huang, Guoming Zhang, Hui Gao, Jinhao Chi, Xiaoqin Zhou, Zijian |
| Author_xml | – sequence: 1 givenname: Guoming surname: Huang fullname: Huang, Guoming email: jhgao@xmu.edu.cn organization: State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China. jhgao@xmu.edu.cn – sequence: 2 givenname: Juan surname: Hu fullname: Hu, Juan – sequence: 3 givenname: Hui surname: Zhang fullname: Zhang, Hui – sequence: 4 givenname: Zijian surname: Zhou fullname: Zhou, Zijian – sequence: 5 givenname: Xiaoqin surname: Chi fullname: Chi, Xiaoqin – sequence: 6 givenname: Jinhao surname: Gao fullname: Gao, Jinhao |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24287667$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkEtLxDAYRYOMOA_d-AMky3FRzaNJmqUM6ggDbrovafK1Rtq0Jq0w_94BR3B1LpfDXdw1WoQhAEK3lDxQwvWj5SGSXGoKF2jFSE4yzhVb_MtLtE7pkxCpueRXaMlyVigp1Qod9r796I64N22AyVvs4xCwNbH2DnAwYRhNPPUdJGwShqYBO_lvwOWW3WM7hCmaNGHTQpjSNbpsTJfg5swNKl-ey90-O7y_vu2eDtkopMoc6IISpwra8EKAstKpJhdW1rUTWoDQDphizYkUCqIAhBPKupoKoahQfIO2v7NjHL5mSFPV-2Sh60yAYU4VzTVRXEhBTurdWZ3rHlw1Rt-beKz-DuA_Jjtd0g |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1039/c3nr04691e |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Engineering |
| EISSN | 2040-3372 |
| ExternalDocumentID | 24287667 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- 0-7 0R~ 29M 4.4 53G 705 7~J AAEMU AAIWI AAJAE AANOJ AARTK AAWGC AAXHV ABASK ABDVN ABEMK ABJNI ABPDG ABRYZ ABXOH ACGFS ACIWK ACLDK ADMRA ADSRN AEFDR AENEX AENGV AESAV AETIL AFLYV AFOGI AFRDS AFRZK AFVBQ AGEGJ AGRSR AHGCF AKBGW AKMSF ALMA_UNASSIGNED_HOLDINGS ALUYA ANBJS ANUXI APEMP ASKNT AUDPV AZFZN BLAPV BSQNT C6K CGR CUY CVF DU5 EBS ECGLT ECM EE0 EF- EIF EJD F5P GGIMP H13 HZ~ H~N J3G J3H J3I NPM O-G O9- OK1 P2P RAOCF RCNCU RNS RPMJG RSCEA RVUXY 7X8 |
| ID | FETCH-LOGICAL-p567-de9810d781f385e7c6d7f45c6bbd595e59de272f59d1e807ee5d57cdb15571573 |
| ISSN | 2040-3372 |
| IngestDate | Thu Jul 10 22:17:03 EDT 2025 Mon Jul 21 05:55:48 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-p567-de9810d781f385e7c6d7f45c6bbd595e59de272f59d1e807ee5d57cdb15571573 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 24287667 |
| PQID | 1490735650 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_1490735650 pubmed_primary_24287667 |
| PublicationCentury | 2000 |
| PublicationDate | 2014-Jan-21 20140121 |
| PublicationDateYYYYMMDD | 2014-01-21 |
| PublicationDate_xml | – month: 01 year: 2014 text: 2014-Jan-21 day: 21 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Nanoscale |
| PublicationTitleAlternate | Nanoscale |
| PublicationYear | 2014 |
| SSID | ssj0069363 |
| Score | 1.861692 |
| Snippet | This paper reports that iron carbide nanoparticles with high air-stability and strong saturation magnetization can serve as effective T2 contrast agents for... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 726 |
| SubjectTerms | Animals Carbon Compounds, Inorganic - chemistry Contrast Media - chemistry Humans Iron Compounds - chemistry Liver Diseases - diagnostic imaging Magnetic Resonance Imaging Magnetics Mice Mice, Inbred BALB C Nanoparticles - chemistry Nanoparticles - ultrastructure Particle Size Radiography Signal-To-Noise Ratio |
| Title | Highly magnetic iron carbide nanoparticles as effective T(2) contrast agents |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/24287667 https://www.proquest.com/docview/1490735650 |
| Volume | 6 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ1Lb9QwEIAtaC9wqHi3UJCROIBWKbEdx8mxqgoLqjgFqeKy8mNSLWKTVXf3QH99x3G8SYFKwCWJnJfkz5qHPTMm5I1Ma1SSGUtA6jLJeCoTVHo6SUvDawFooOuu2ueXfPo1-3wuz4edCrvskrU5sld_zCv5H6rYhlx9luw_kN1-FBvwGvniEQnj8a8Y-yCNHz8nC33R-FzEiU9Z87WmzdzBpNENOsR93JvfTiaEbvhIoQrNSu7nA7pAdb1aT_RFrOkULVUUu-0KAY7A91PLHzftIiq8rj1kdwzDbDsJPd3Mh7a2e-7b_HsckP1cA_PxKUlIYD6CTiZxH4AohLohQPPROOEjYahCLvxvQjoVvsapFc2ld84ZjB_CDl4uOlzcO3N52Kvjl5LY8dZdssuV8qvzu8en1aezqILzUuQi1qIV5fvhV772c__y7S5FZ1pUD8he7xPQ48DqIbkDzSNyf1Qp8jE5C6hpRE09atqjpjdQU72iW9S0esvf0YiZBsxPSPXhtDqZJv1GGMlSoh5zUBYsdapgtSgkKJs7VWfS5sY4WUqQpQOueI1nBkWqAKSTyjqDtqJiUomnZKdpG9gnVOYW0EZ0mdVFphk3zEruwEgBOeeWH5DXsVNmKGf84pFuoN2s0EUsURug-Z8ekGeht2bLUBBlFrv0-a13XpB7w3g6JDvryw28RGtubV717K4BHbtKnA |
| linkProvider | Royal Society of Chemistry |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Highly+magnetic+iron+carbide+nanoparticles+as+effective+T%282%29+contrast+agents&rft.jtitle=Nanoscale&rft.au=Huang%2C+Guoming&rft.au=Hu%2C+Juan&rft.au=Zhang%2C+Hui&rft.au=Zhou%2C+Zijian&rft.date=2014-01-21&rft.eissn=2040-3372&rft.volume=6&rft.issue=2&rft.spage=726&rft_id=info:doi/10.1039%2Fc3nr04691e&rft_id=info%3Apmid%2F24287667&rft.externalDocID=24287667 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2040-3372&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2040-3372&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2040-3372&client=summon |