Highly magnetic iron carbide nanoparticles as effective T(2) contrast agents

This paper reports that iron carbide nanoparticles with high air-stability and strong saturation magnetization can serve as effective T2 contrast agents for magnetic resonance imaging. Fe5C2 nanoparticles (~20 nm in diameter) exhibit strong contrast enhancement with an r2 value of 283.2 mM(-1) S(-1)...

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Bibliographic Details
Published inNanoscale Vol. 6; no. 2; p. 726
Main Authors Huang, Guoming, Hu, Juan, Zhang, Hui, Zhou, Zijian, Chi, Xiaoqin, Gao, Jinhao
Format Journal Article
LanguageEnglish
Published England 21.01.2014
Subjects
Animals
Carbon Compounds, Inorganic - chemistry
Contrast Media - chemistry
Humans
Iron Compounds - chemistry
Liver Diseases - diagnostic imaging
Magnetic Resonance Imaging
Magnetics
Mice
Mice, Inbred BALB C
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Particle Size
Radiography
Signal-To-Noise Ratio
Online AccessGet full text
ISSN2040-3372
2040-3372
DOI10.1039/c3nr04691e

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Summary:This paper reports that iron carbide nanoparticles with high air-stability and strong saturation magnetization can serve as effective T2 contrast agents for magnetic resonance imaging. Fe5C2 nanoparticles (~20 nm in diameter) exhibit strong contrast enhancement with an r2 value of 283.2 mM(-1) S(-1), which is about twice as high as that of spherical Fe3O4 nanoparticles (~140.9 mM(-1) S(-1)). In vivo experiments demonstrate that Fe5C2 nanoparticles are able to produce much more significant MRI contrast enhancement than conventional Fe3O4 nanoparticles in living subjects, which holds great promise in biomedical applications.
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ISSN:2040-3372
2040-3372
DOI:10.1039/c3nr04691e