Ultrastructural changes in endothelial cells of blood capillaries of the Walker 256 carcinosarcoma while treated with melatonin

In Wistar rats with transplanted Walker 256 carcinosarcoma a use of melatonin as monoagent causes changes in intracellular organization of endothelial cells: reduced volume density of mitochondria, granular cytoplasmic network, micropinocytic vesicles, reduced the number density of free and attached...

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Bibliographic Details
Published inVoprosy onkologij Vol. 60; no. 2; p. 80
Main Authors Ovsianko, E V, Pustovetova, M G, Samsonova, E N, Ovsianko, Ia U, Fedina, R G, Kulishenko, A O, Vinogradov, A S
Format Journal Article
LanguageRussian
Published Russia (Federation) 2014
Subjects
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - pharmacology
Apoptosis - drug effects
Capillaries - pathology
Carcinoma 256, Walker - pathology
Carcinoma 256, Walker - ultrastructure
Cytoplasm - drug effects
Endothelial Cells - ultrastructure
Male
Melatonin - administration & dosage
Melatonin - pharmacology
Mitochondria - drug effects
Pinocytosis - drug effects
Rats
Ribosomes - drug effects
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Summary:In Wistar rats with transplanted Walker 256 carcinosarcoma a use of melatonin as monoagent causes changes in intracellular organization of endothelial cells: reduced volume density of mitochondria, granular cytoplasmic network, micropinocytic vesicles, reduced the number density of free and attached ribosomes, which leads to increased apoptosis of tumor cells of Walker 256 carcinosarcoma.
ISSN:0507-3758