Complex morphological diagnostics of tuberculosis and sarcoidosis of the lungs

Differential diagnosis of disseminated lung diseases, particularly tuberculosis and sarcoidosis, presents certain difficulties for clinicians. In the verification of the diagnosis a decisive role belongs to the morphological study, for which the most commonly used material is transbronchial biopsy....

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Bibliographic Details
Published inVoenno-medicinskij ̆zurnal Vol. 333; no. 3; p. 24
Main Authors Lepekha, L N, Burtseva, S A, Evgushchenko, G V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.2012
Subjects
Bronchoscopy
Diagnosis, Differential
Humans
Macrophages, Alveolar - pathology
Sarcoidosis, Pulmonary - microbiology
Sarcoidosis, Pulmonary - pathology
Thoracotomy
Tuberculosis, Pulmonary - microbiology
Tuberculosis, Pulmonary - pathology
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Summary:Differential diagnosis of disseminated lung diseases, particularly tuberculosis and sarcoidosis, presents certain difficulties for clinicians. In the verification of the diagnosis a decisive role belongs to the morphological study, for which the most commonly used material is transbronchial biopsy. Diagnostic signs of active disseminated pulmonary tuberculosis are presence of different-sized granulomas with signs merger, necrosis, infiltration of polymorphonuclear leukocytes, weakly expressed fibrillogenesis. Cytological markers of a specific process are young biosinteziruyuschie macrophages and acid-fast bacilli. The diagnostic features of pulmonary sarcoidosis are monomorphic granulomas with no tendency to merge and necrotisation expressed fibrosis and hyalinization processes. Cytological marker for the disease is the high content of epithelioid cells with signs of secretion.
ISSN:0026-9050