Cardioprotective effects of KB-R7943 : a novel inhibitor of the reverse mode of Na+/Ca2+ exchanger

The novel inhibitor of the reverse mode of the Na+/Ca2+ exchanger (NCE) KB-R7943 (KB) was tested in isolated rat cardiomyocytes exposed to 80 min of simulated ischemia {substrate-free anoxia, extracellular pH (pHo) of 6.4} and 15 min of reoxygenation (pHo 7.4).

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Bibliographic Details
Published inAmerican journal of physiology. Heart and circulatory physiology Vol. 45; no. 6; pp. H1868 - H1876
Main Authors LADILOV, Y, HAFFNER, S, BALSER-SCHAFER, C, MAXEINER, H, PIPER, H. M
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.06.1999
Subjects
Biological and medical sciences
Calcium
Cardiovascular disease
Cardiovascular system
Heart
Medical sciences
Miscellaneous
Pharmacology. Drug treatments
Sodium
Heart
Rat
Rodentia
Cardioprotective agent
Cardiovascular disease
Coronary heart disease
Myocardial disease
Myocyte
Vascular disease
Vertebrata
Mammalia
Calcium ion
Reperfusion
Ischemia
Animal
Sodium ion
Myocardium
Circulatory system
Inhibition
Lesion
Cation exchanger
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Summary:The novel inhibitor of the reverse mode of the Na+/Ca2+ exchanger (NCE) KB-R7943 (KB) was tested in isolated rat cardiomyocytes exposed to 80 min of simulated ischemia {substrate-free anoxia, extracellular pH (pHo) of 6.4} and 15 min of reoxygenation (pHo 7.4).
ISSN:0363-6135
1522-1539