PECULIARITIES OF THE MESENTERY MICROCIRCULATORY BED RESPONSE TO ISONIAZID INTOXICATION

An original technique has been developed for the biomicroscopy of small-intestine mesentery blood vessels in rats. Using this method, specific features of mic- rocirculatory process disturbances caused by isoniazid in high doses have been elucidated for the first time. It is established that intraga...

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Bibliographic Details
Published inĖksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 78; no. 12; p. 34
Main Authors Muzalevskaya, E N, Nikolaevskii, V A, Chernov, Yu N
Format Journal Article
LanguageRussian
Published Russia (Federation) 2015
Subjects
Animals
Animals, Outbred Strains
Erythrocyte Aggregation - drug effects
Gastrointestinal Hemorrhage - chemically induced
Gastrointestinal Hemorrhage - pathology
Gastroparesis - chemically induced
Gastroparesis - pathology
Intestine, Small - blood supply
Intestine, Small - drug effects
Intestine, Small - pathology
Isoniazid - toxicity
Male
Mesentery - blood supply
Mesentery - drug effects
Mesentery - pathology
Microcirculation - drug effects
Microscopy
Rats
Stomach - drug effects
Stomach - pathology
Transendothelial and Transepithelial Migration - drug effects
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Summary:An original technique has been developed for the biomicroscopy of small-intestine mesentery blood vessels in rats. Using this method, specific features of mic- rocirculatory process disturbances caused by isoniazid in high doses have been elucidated for the first time. It is established that intragastric introduction of iso- niazid (single daily dose of 542 mg/kg for 6 days) leads to pronounced disturbances of the microcirculatory process, accompanied by intravascular aggregation of erythrocytes, stasis, destructive changes in vessel walls, diapedesis, and hemorrhage over an area of (1.9-9.9) x 10⁻³ mm².
ISSN:0869-2092