Application prospect of reaction engineering approach in studying drying behavior of single droplet during spray drying of traditional Chinese medicine

• Published in: Zhongguo zhongyao zazhi Vol. 48; no. 22; p. 6011
• Main Authors: Tang, Pei-Yu, Wang, Xue-Cheng, Wang, Xiao-Hui, Xu, Liu-Feng, Li, Yuan-Hui, Wu, Zhen-Feng, Yang, Ming
• Format: Journal Article
• Language: Chinese
• Published: China 01.11.2023
• Subjects: single droplet drying; process optimization; traditional Chinese medicine; reaction engineering method; spray drying
• ISSN: 1001-5302
• DOI: 10.19540/j.cnki.cjcmm.20230901.301

Spray drying technology is one of the most commonly used unit operations in the production of traditional Chinese medicine(TCM) preparations, offering advantages such as short drying time and uniform product quality. However, due to the properties of TCM extracts, such as high viscosity, strong hygroscopicity, and poor flowability, there is limited scope to solve the problems of wall adhesion and clumping in spray drying from the macroscopic perspective of pharmaceutical production. Therefore, it has become a trend to study and optimize the spray drying process from the microscopic point of view by investigating single droplet evaporation behavior. Based on the reaction engineering approach(REA), the single droplet drying system, as a novel method for studying droplets, collects parameter data on individual TCM droplets during the drying process and uses the REA to process the data and establish predictive models. This approach is crucial for understanding the mechanism of TCM spray drying. This paper summari