Studies on fingerprints and efficacy-related substance of classical prescription Zhuru Decoction

• Published in: Zhongguo zhongyao zazhi Vol. 45; no. 23; p. 5599
• Main Authors: Xu, Jin-Guo, Huang, Zi-Yan, Shen, Qian-Neng, Li, Lin, Wang, Qiao-Han, Wang, Lu, Lu, Tu-Lin, Mao, Chun-Qin
• Format: Journal Article
• Language: Chinese
• Published: China 01.12.2020
• Subjects: Drugs, Chinese Herbal; Glycyrrhizic Acid; Prescriptions; Quality Control; classical prescription; fingerprint chromatography; Zhuru Decoction; quality control; efficacy related substance; network pharmacology
• ISSN: 1001-5302
• DOI: 10.19540/j.cnki.cjcmm.20200921.301

Based on fingerprint and network pharmacology,the whole process quality control of Zhuru Decoction was conducted and efficacy-related substances were predicted.The fingerprints of raw materials,decoction pieces and Zhuru Decoction were established,and 25 common peaks were identified,including 9 common chromatographic peaks of 3'-hydroxy puerarin,puerarin,3'-methoxy puerarin,puerarin,aperioside,daidzin,daidzein,liquiritin,glycyrrhizic acid and 6-gingerol, with similarity all greater than 0.95.The main groups of pharmacodynamic substances can be transferred from raw materials,decoction pieces to Zhuru Decoction step by step,with a clear affiliation relationship.Based on the testability and traceability,the active ingredients were screened,and the network relationship of "component-target-pathway" was constructed and analyzed for the nine chemical components screened by network pharmacology.The enriched pathways included energy metabolism,alcoholism,and smooth muscle contraction and relaxation-related pathways.T