Gene expression signature analysis of peripheral blood mononuclear cells from patients with for high altitude pulmonary hypertension and value for potential drug selection

• Published in: Zhōnghuá xīnxuèguănbìng zázhì Vol. 50; no. 6; p. 577
• Main Authors: Wu, X H, Chen, Z R, He, Z Y, Dong, Y, Yang, Y, Zhao, Q Y, Yang, W, Wang, L Y, Fu, C J, Yang, X D, Liu, H
• Format: Journal Article
• Language: Chinese
• Published: China 24.06.2022
• ISSN: 0253-3758
• DOI: 10.3760/cma.j.cn112148-20220328-00215

To investigate the gene expression characteristics of peripheral blood mononuclear cells from patients with high altitude pulmonary hypertension (HAPH) in Naxi residents living in Lijiang, Yunnan, and to explore the underlying pathogenesis and value for potential drug selection. This is a case-control study. Six patients with HPAH (HPAH group) and 4 normal subjects (control group) were selected from the Naxi residents who originally lived in Lijiang, Yunnan Province. The general clinical data of the two groups were collected, and the related indexes of pulmonary artery pressure were collected. Peripheral blood mononuclear cells of the subjects were collected for RNA sequencing. The differences on gene expression, regulatory network of transcription factors and drug similarity between the two groups were compared. The results were compared with the public data of idiopathic pulmonary arterial hypertension (IPAH). Biological processes and signal pathways were analyzed and compared between HPAH and IPAH patients