Epithelioid sarcoma with mesothelial and lymphatic endothelial differentiation: a clinicopathologic analysis of 10 cases

• Published in: Zhonghua bing li xue za zhi Vol. 46; no. 4; p. 228
• Main Authors: Ke, Z Y, Yang, S J
• Format: Journal Article
• Language: Chinese
• Published: China 08.04.2017
• Subjects: Adolescent; Adult; Aged; Arm; Biomarkers, Tumor; Cell Differentiation; Child; Desmin - analysis; Diagnosis, Differential; Endothelium, Lymphatic - pathology; Female; Humans; Immunohistochemistry; Keratins - analysis; Male; Middle Aged; Mucin-1 - analysis; Neoplasm Proteins - analysis; S100 Proteins - analysis; Sarcoma - chemistry; Sarcoma - diagnosis; Sarcoma - pathology; Thigh; Vascular Endothelial Growth Factor Receptor-3 - analysis; Immunohistochemistry; Endothelium, lymphatic; Sarcoma; Diagnosis, differential; Endothelium
• ISSN: 0529-5807
• DOI: 10.3760/cma.j.issn.0529-5807.2017.04.003

To investigate the multidirectional differentiation potential in epithelioid sarcoma (ES), with special emphasis on its mesothelial and lymphatic endothelial markers expression. Ten cases of distal-type ES were included. The clinical, histological, and immunohistochemical(including mesothelial and lymphatic endothelial markers expression)features and follow-up data were evaluated. The patients aged between 8 to 66 years. Five cases were male and five were female. The tumors were located at the palm (2 cases), wrist (3 cases), upper arm (2 cases), poplitealfossa (1 case), lower leg (1 case) and thigh (1 case), respectively. Clinically, most cases presented as painful, firm subcutaneous nodules. Histologically, the tumors were mainly composed of epithelioid, rhabdoid, spindle, or transitional cells, with abundant eosinophilic cytoplasm, oval and vesicular nucleus, and one or more prominent nucleoli. They were arranged in nodular, diffuse nodular or sheet like growth patterns, frequently with necrosis at the cen