Study of Rhizoma Darynaria on regulation of cellular immune function in immunosuppressive mice

To study the effect of Rhizoma Drynaria ethanol extract on regulation of cellular immune functions in cyclophosphamide-induced immunosuppressive mice. A total of 60 kunming mice were randomly divided into six groups:normal control group, model group, positive control group( levamisole, 0. 05 g / kg)...

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Bibliographic Details
Published inWei sheng yan jiu Vol. 46; no. 1; p. 84
Main Authors Zhao, Gan, He, Guanlan, Lu, Chunyuan, Lao, Lingling, Wei, Jinbin
Format Journal Article
LanguageChinese
Published China 01.01.2017
Subjects
cellular immune
immunosuppression
regulation
Rhizoma drynaria ethanol extract
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Summary:To study the effect of Rhizoma Drynaria ethanol extract on regulation of cellular immune functions in cyclophosphamide-induced immunosuppressive mice. A total of 60 kunming mice were randomly divided into six groups:normal control group, model group, positive control group( levamisole, 0. 05 g / kg) and low-, medium- and high-dose Rhizoma Drynaria ethanol extract-treated groups( 2. 5, 5, 10 g / kg). The mice in the four administration group were administered with 10 mL / kg of the drug for 20 days. Except normal control group, the mice in the other 5 groups were intraperitoneally injected( ip) with cyclophosphamide to establish immunosuppression model. After the end of the experiment, the indices of lymphocyte proliferation capacity and delayed type hypersensitivity were detected, speen histological structure and Tlymphocyte subsets CD_4~+, CD_8~+T cells in peripheral blood were measured. The relativemRNA expression of Interleukin 4( IL-4) and Interferon-γ( IFN-γ) in the spleen tissues were detected. Rhizoma
ISSN:1000-8020