New options for therapeutic revascularization in lower extremity limb ischemia linked to the diabetic foot syndrome by autologous stem cell transplantation

Type 2 diabetes incidence is growing worldwide. It is in up to 50% cases linked with diabetic foot syndrome. This is associated with peripheral neuropathy and peripheral artery disease which increases risk of defects with impaired healing. Resulting high number of amputations has major influence on...

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Published inČasopis lékařů českých Vol. 154; no. 4; p. 161
Main Authors Svěcený, Jakub, Syková, Eva, Tichý, Michal, Laštůvka, Jiří
Format Journal Article
LanguageCzech
Published Czech Republic 2015
Subjects
Diabetic Foot - surgery
Humans
Stem Cell Transplantation - methods
Syndrome
Vascular Surgical Procedures - methods
Wound Healing
lower extremity limb ischemia - stem cells - critical limb ischemia - diabetes mellitus
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Summary:Type 2 diabetes incidence is growing worldwide. It is in up to 50% cases linked with diabetic foot syndrome. This is associated with peripheral neuropathy and peripheral artery disease which increases risk of defects with impaired healing. Resulting high number of amputations has major influence on the quality of life and constitutes serious clinical issue. In recent years numerous clinical studies have shown positive effect of new treatment modality using regenerative potential of the autologous stem cells transplantation. This review tries to summarize existing results of therapeutic revascularization using stem cell and to outline mechanism of their action.
ISSN:0008-7335