Two new sesquiterpenes in Qi-nan Aquilariae Lignum Resinatum

This study aimed to investigate the chemical constituents of supercritical extract from Qi-nan Aquilariae Lignum Resinatum by silica gel column chromatography, thin-layer chromatography, and semi-preparative high-performance liquid chromatography. One new elemane-type and one new eudesmane-type sesq...

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Published inZhongguo zhongyao zazhi Vol. 48; no. 23; p. 6403
Main Authors Chen, De-Li, Ma, Guo-Xu, Liu, Hui-Mei, Wang, Can-Hong, Liu, Yang-Yang, Yang, Yun, Wei, Jian-He
Format Journal Article
LanguageChinese
Published China 01.12.2023
Subjects
Animals
Molecular Structure
Qi
Rats
Sesquiterpenes - pharmacology
elemane-type sesquiterpene
neuroprotection
eudesmane-type sesquiterpene
Qi-nan Aquilariae Lignum Resinatum
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Summary:This study aimed to investigate the chemical constituents of supercritical extract from Qi-nan Aquilariae Lignum Resinatum by silica gel column chromatography, thin-layer chromatography, and semi-preparative high-performance liquid chromatography. One new elemane-type and one new eudesmane-type sesquiterpene compounds were isolated from the extract, and their structures were identified by MS, UV, IR, NMR, and ECD spectroscopic techniques, and named aquqinanol C(1) and aquqinanol D(2). Both compounds are novel compounds. The neuroprotective effect of the compounds on CORT-induced PC12 cell damage was determined in vitro. The results showed that compounds 1 and 2 exhibited a certain protective effect against CORT-induced damage in PC12 cells.
ISSN:1001-5302
DOI:10.19540/j.cnki.cjcmm.20230618.203