Quality evaluation of Gualou Guizhi decoction based on chemical compositions and biological effects

The paper was aimed to establish a quality evaluation model for Gualou Guizhi decoction based on the chemical compositions and biological effects. Ultra high performance liquid chromatograph-mass spectrometer was used to analyze and determine 24 kinds of chemical compositions in Gualou Guizhi decoct...

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Bibliographic Details
Published inZhongguo zhongyao zazhi Vol. 42; no. 10; p. 1877
Main Authors Li, Huang, Qiao, Li-Fei, Zhang, Yu-Qin, Xu, Wen, Xu, Wei, Chu, Ke-Dan, Lin, Yu
Format Journal Article
LanguageChinese
Published China 01.05.2017
Subjects
UPLC-MS
Gualou Guizhi decoction
Zebrafish neuronal injury model
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Summary:The paper was aimed to establish a quality evaluation model for Gualou Guizhi decoction based on the chemical compositions and biological effects. Ultra high performance liquid chromatograph-mass spectrometer was used to analyze and determine 24 kinds of chemical compositions in Gualou Guizhi decoction, and then, biological activity effect was quantitatively assessed in a zebrafish neuronal injury model which was induced by mycophenolate mofetil (MMF). As a result, the established method for quality evaluation of Gualou Guizhi decoction based on the chemical compositions and biological effects is feasible, stable and reliable, which can provide reference for quality control of compound Chinese medicines.
ISSN:1001-5302
DOI:10.19540/j.cnki.cjcmm.20170223.002