Hepatotoxicity of cytostatic drugs in treatment of oncology patients

A hepatotoxicity can be observed at the use of different groups of antitumoral drugs. Cytotoxicity drugs have a leading place in relation to incidence and severity of liver damage. During chemotherapy the development of hepatotoxicity is caused by thedamage of the liver parenchymal cells with fatty...

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Bibliographic Details
Published inLikars'ka sprava no. 2; pp. 14 - 24
Main Authors Syvak, L A, Lial'kin, S A, Klimanov, M Iu, Hubareva, H O, Askol's'kyĭ, A V, Kasap, N V, Maĭdanevych, N M
Format Journal Article
LanguageUkrainian
Published Ukraine 01.03.2013
Subjects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Antineoplastic Combined Chemotherapy Protocols - toxicity
Chemical and Drug Induced Liver Injury - etiology
Chemical and Drug Induced Liver Injury - pathology
Cytostatic Agents - therapeutic use
Cytostatic Agents - toxicity
Humans
Liver - drug effects
Liver - pathology
Neoplasms - drug therapy
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Summary:A hepatotoxicity can be observed at the use of different groups of antitumoral drugs. Cytotoxicity drugs have a leading place in relation to incidence and severity of liver damage. During chemotherapy the development of hepatotoxicity is caused by thedamage of the liver parenchymal cells with fatty degeneration, necrosis of the liver tissue, and cholestasis. The study of the mechanisms of development, clinical course and laboratory manifestations of hepatotoxicity of chemotherapy will lead to its prevention or reduction, which will improve the immediate and long-term results of treatment of patients with cancer.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1019-5297