Mechanism of the Notch signaling pathway in enhancing the efficacy of chemotherapy drugs in osteosarcoma

Osteosarcoma is the most common malignant tumors of bone. Since 1970s, researchers had used chemotherapy drugs to treat osteosarcoma. However, multidrug resistance is a major adverse reaction that affects the efficacy of chemotherapy drugs, leading to the reduced survival rate of osteosarcoma patien...

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Bibliographic Details
Published inZhong nan da xue xue bao. Journal of Central South University. Yi xue ban Vol. 45; no. 10; p. 1234
Main Author Song, Yichang
Format Journal Article
LanguageEnglish
Published China 28.10.2020
Subjects
Bone Neoplasms - drug therapy
Cell Line, Tumor
Cell Proliferation
Humans
Osteosarcoma - drug therapy
Pharmaceutical Preparations
Receptors, Notch - genetics
Signal Transduction
Notch signaling pathway
multidrug resistance
chemotherapy
osteosarcoma
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Summary:Osteosarcoma is the most common malignant tumors of bone. Since 1970s, researchers had used chemotherapy drugs to treat osteosarcoma. However, multidrug resistance is a major adverse reaction that affects the efficacy of chemotherapy drugs, leading to the reduced survival rate of osteosarcoma patients. The Notch signaling pathway plays an important role in osteosarcoma proliferation, which affects tumor resistance by reducing intracellular drug accumulation, regulating epithelial-mesenchymal transition, dysregulating microRNA, disrupting the expression of apoptosis genes, and regulating tumor stem cells.
ISSN:1672-7347
DOI:10.11817/j.issn.1672-7347.2020.190147