ST segment elevation myocardial infarction in women

• Published in: Annales de cardiologie et d'angeiologie Vol. 65; no. 6; p. 385
• Main Author: Manzo-Silberman, S
• Format: Journal Article
• Language: French
• Published: France 01.12.2016
• Subjects: Acute Coronary Syndrome - mortality; Adult; Age Factors; Aged; Cause of Death; Comorbidity; Cross-Sectional Studies; Female; France; Hospitalization - statistics & numerical data; Humans; Life Style; Male; Prognosis; Risk Factors; Sex Factors; ST Elevation Myocardial Infarction - mortality; Myocardial infarction; Women; Mortality; Mortalité; Femmes; Infarctus du myocarde; Revascularisation; Acute coronary syndromes; Syndrome coronaire aigu; Revascularization
• ISSN: 1768-3181
• DOI: 10.1016/j.ancard.2016.10.018

In France, coronary disease is responsible for 11.9 deaths/100,000 women aged 35 to 74 years old every year. In France, the number of hospitalizations and deaths for myocardial infarction (MI) increases more significantly in women, particularly under 65. To date, women with MI were 5-10 years older than men, with more risk factors and comorbidities, especially regarding diabetes, high blood pressure and lipid profile. However, a recent comparative study of the FAST-MI registry notes a change in the characteristics of these patients with more and more young women, active smoking and obesity. Their symptoms include more often atypics ones. They also have the particularity of a higher frequency of MI without obstructive lesion. Though, even at the same age, women have a worse prognosis with significantly higher mortality rate, especially early, in-hospital, than those of men. However, there are means to implement in order to reduce complications rate and improve the prognosis through information campaign and primary prevention screening and appropriate care and correction of risk factors. It is also important to raise awareness of general population and care actors about women MI risk even young, about its atypical forms and the necessity of to rapid and aggressive care processes. A better understanding of specific pathophysiological mechanisms appears mandatory and should be supported by prospective dedicated studies.