TARTRAT-RESISTANT ACID PHOSPHATASE AS BONE'S RESORBTION MARKER IN PATIENTS WITH BONE METASTASES

• Published in: Likars'ka sprava no. 5-6; pp. 104 - 109
• Main Authors: Dedkov, A G, Boychuk, S I, Stakhovsky, E A, Kukushkina, M N, Kovalchuk, P A
• Format: Journal Article
• Language: Russian
• Published: Ukraine 01.07.2015
• Subjects: Acid Phosphatase - blood; Acid Phosphatase - genetics; Biomarkers, Tumor - blood; Biomarkers, Tumor - genetics; Bone Density Conservation Agents - therapeutic use; Bone Neoplasms - blood; Bone Neoplasms - diagnosis; Bone Neoplasms - drug therapy; Bone Neoplasms - secondary; Bone Resorption - blood; Bone Resorption - diagnosis; Bone Resorption - drug therapy; Bone Resorption - pathology; Carcinoma, Renal Cell - blood; Carcinoma, Renal Cell - diagnosis; Carcinoma, Renal Cell - drug therapy; Carcinoma, Renal Cell - secondary; Diphosphonates - therapeutic use; Early Diagnosis; Female; Gene Expression; Humans; Isoenzymes - blood; Isoenzymes - genetics; Kidney Neoplasms - blood; Kidney Neoplasms - diagnosis; Kidney Neoplasms - drug therapy; Kidney Neoplasms - pathology; Male; Middle Aged; Retrospective Studies; Tartrate-Resistant Acid Phosphatase
• ISSN: 1019-5297

Determination of serum markets of bone resorption in patients, with renal cancer after radical surgery can improve the accuracy of early diagnosis of bone metastases, assess the extent of metastatic bone lesions, and monitoring of bisphosphonates treatment. These data suggest promising activity for tartrat-resistant acid phosphatase (TRAP-5b) of early detection of bone metastasis.