EVALUATED SERUM LEVELS OF BRAIN-DERIVED NEUROTROPHIC FACTOR IN MEN AND WOMEN WITH CHRONIC BRAIN ISCHEMIA

We measured serum levels of brain-derived neurotrophic factor (BDNF) in 25 elderly women in 23 men-patients with chronic brain ischemia (CBI), and in 26 gender and age matched healthy controls. The serum levels of BDNF were significantly lower in patients with CBI as compared to healthy controls. Th...

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Bibliographic Details
Published inAdvances in gerontology = Uspekhi gerontologii Vol. 28; no. 1; p. 146
Main Authors Abramenko, Iu V, Sliusar', T A, Iakovlev, N A
Format Journal Article
LanguageRussian
Published Russia (Federation) 2015
Subjects
Aging - blood
Biomarkers - blood
Brain Ischemia - blood
Brain Ischemia - complications
Brain Ischemia - physiopathology
Brain-Derived Neurotrophic Factor - blood
Chronic Disease
Cognition - physiology
Cognition Disorders - blood
Cognition Disorders - etiology
Cognition Disorders - physiopathology
Female
Humans
Male
Middle Aged
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Summary:We measured serum levels of brain-derived neurotrophic factor (BDNF) in 25 elderly women in 23 men-patients with chronic brain ischemia (CBI), and in 26 gender and age matched healthy controls. The serum levels of BDNF were significantly lower in patients with CBI as compared to healthy controls. The serum levels of BDNF were also lower in men with CBI (7815,14 x 10 ng/ml) in comparison to women-patients (8466,05 x 10 ng/ml). The average serum levels of BDNF in patients with CBI proved to be significantly correlated with kinesthetic praxis disorders (p < 0.05), degree of cognitive impairment (p < 0.01), depression level (p < 0.01), especially in men. The obtained data may be important for individualization of therapeutic intervention.
ISSN:1561-9125