New approaches to treatment for malignant tumors using perfusion technologies

• Published in: Voprosy onkologij Vol. 62; no. 2; p. 214
• Main Authors: Belyaev, A M, Gafton, G I, Kireeva, G S, Senchik, K Yu, Guseinov, K D, Levchenko, E V, Karachun, A M, Gulyaev, A V, Semiletova, Yu V, Gafton, I G, Mamontov, O Yu, Kalinin, P S
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2016
• Subjects: Chemotherapy, Cancer, Regional Perfusion; Disease-Free Survival; Female; Humans; Male; Neoplasms - mortality; Neoplasms - therapy; Survival Rate
• ISSN: 0507-3758

The paper summarizes and analyzes the results of complex treatment of patients with malignant tumors performed in the N.N.Petrov Research Institute of Oncology using perfusion technologies. Safety and efficacy data on various chemoperfusion is presented: intraperitoneal chemoperfusion combined with cytoreductive surgery in patients with locally advanced and disseminated gastric cancer, recurrent ovarian cancer and pseudomyxoma peritonei; isolated lung perfusion combined with metastasectomy in patients with lung metastases; isolated limb perfusion with/without cytoreduction in patients with locally advanced skin melanoma and locally advanced soft-tissue sarcoma. The conclusion is made that both intraperitoneal and isolated chemoperfusions are not associated with higher incidence of intra- and postoperative morbidity. However safety of the procedures could be increased through optimizing tactics of surgical procedures prior to chemoperfusions. The use of perfusion technologies provides significant survival advantage in patients who can’t benefit from conservative treatment.