Relationship between white matter lesions and theresponse of cerebral spinal fluid tap test and clinical features in the patients with idiopathic normal pressure hydrocephalus

• Published in: Zhong hua yi xue za zhi Vol. 102; no. 11; p. 774
• Main Authors: Liu, C Y, Wei, J J, Huang, X Y, Dong, L L, Li, J, Wang, J, Lei, D, Mao, C H, Hou, B, Feng, F, Cui, L Y, Gao, J
• Format: Journal Article
• Language: Chinese
• Published: China 22.03.2022
• Subjects: Aged; Anisotropy; Diffusion Tensor Imaging - methods; Female; Humans; Hydrocephalus, Normal Pressure - surgery; Magnetic Resonance Imaging; Male; Middle Aged; White Matter - pathology
• ISSN: 0376-2491
• DOI: 10.3760/cma.j.cn112137-20210723-01649

To explore the relationship between white matter lesions and clinical features and response of cerebral spinal fluid (CSF) tap test in patients with idiopathic normal pressure hydrocephalus(iNPH). Possible iNPH patients were enrolled from outpatients and inpatients in Peking Union Medical College Hospital between 2014 and 2019. All patients underwent detailed neuropsychological and walking assessments, CSF tap test, as well as head magnetic resonance imaging. The Fazekas score of white matter lesions, the fractional anisotropy (FA)and mean diffusivity (MD) values of regions of interest by means ofdiffusion tensor imaging (DTI) were compared between CSF tap test positive and negative response groups. The correlation between DTI parameters and clinical characteristics was analyzed. Forty-three patients (29 male and 14 female, age range: 52-79 years] wererecruited.Compared with the negative group, patients in the positive group tended to have higher Fazekas score of periventricular white matter( =108.00, =0.03),