Spontaneous focal lamina cribrosa defect in glaucoma and its relationship with nonprogressive glaucomatous neuropathy

• Published in: Chung-hua yen k'o tsa chih Vol. 55; no. 5; p. 338
• Main Authors: Sun, Y X, Xie, Y, Liu, X X, Guo, Y Q, Pang, R Q, Zhang, X, Cao, K, Tian, N, Wang, H Z, Zhang, C, Wang, N L
• Format: Journal Article
• Language: Chinese
• Published: China 11.05.2019
• Subjects: Glaucoma, open-angle; Lamina cribrosa defect; Tomography, optical coherence; Visual fields; Intraocular pressure
• ISSN: 0412-4081
• DOI: 10.3760/cma.j.issn.0412-4081.2019.05.007

To investigate the relationship between the spontaneous focal lamina cribrosa (LC) defect and the progression of visual field defect (VFD) in primary open-angle glaucoma (POAG). Case-control study. The patients who were diagnosed as POAG with at least 5 visual field results had been collected from June 2018 to January 2019 at Beijing Tongren Hospital Affiliated to Capital Medical University. Serial imaging by swept source optical coherence tomography B-Scan of the optic discs were acquired at the end of the follow-up and LC defects status were reviewed. Intraocular pressure, mean defects of visual field, central corneal thickness and axis length were recorded in the follow-up duration. Eyes were classified as having either progressive or nonprogressive VFD, and associating factors were evaluated by χ(2) or Fisher's test, mixed-effect model analysis and multivariate Logistical regression analysis. A total of 32 subjects (64 eyes) were enrolled in the study with mean age of (47±14) years, the group consisted of