Randomized controlled trial outcome indicators of traditional Chinese medicine for gastrointestinal dysfunction in sepsis in recent two years

• Published in: Zhongguo zhongyao zazhi Vol. 47; no. 3; p. 819
• Main Authors: Wang, Gui-Qian, Zheng, Hui-Juan, Cao, Ying, Peng, Wei, Yao, Wei-Hai
• Format: Journal Article
• Language: Chinese
• Published: China 01.02.2022
• Subjects: Drugs, Chinese Herbal - therapeutic use; Gastrointestinal Diseases - drug therapy; Humans; Medicine, Chinese Traditional; Randomized Controlled Trials as Topic; Research Design; Sepsis - drug therapy; traditional Chinese medicine; gastrointestinal dysfunction in sepsis; outcome indicator; randomized controlled trial
• ISSN: 1001-5302
• DOI: 10.19540/j.cnki.cjcmm.20211013.501

The purpose of the study is to analyze the outcomes of randomized controlled trial(RCT) of Chinese herbal medicine formula(CHMF) in the treatment of gastrointestinal dysfunction in sepsis in recent two years. We systematically searched four Chinese databases, three English databases, and two clinical trial registries to analyze the reports of outcome indicators of clinical trials, and evaluated the risk of bias by using the ROB tool of Cochrane Collaboration. After screening, 55 clinical RCTs were included. The results showed that the current clinical studies of gastrointestinal dysfunction in sepsis reported the efficacy and safety indicators. The efficacy indicators included APACHE Ⅱ scores, gastrointestinal dysfunction scores, bowel sound scores, and inflammatory indicator such as C-reactive protein and procalcitonin. The safety indicators mainly include gastrointestinal reactions, skin reactions, and other adverse events and adverse reactions. However, there was no distinction between primary and secondar