Increased activity and expression of Ca2+-dependent NOS in renal cortex of ANG II-infused hypertensive rats

We have previously demonstrated that nitric oxide (NO) exerts a greater modulatory influence on renal cortical blood flow in ANG II-infused hypertensive rats compared with normotensive rats. In the present study, we determined nitric oxide synthase (NOS) activities and protein levels in the renal co...

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Bibliographic Details
Published inAmerican journal of physiology. Renal physiology Vol. 46; no. 5; pp. F797 - F804
Main Authors SO YEON CHIN, PANDEY, K. N, SHI, S.-J, KOBORI, H, MORENO, C, NAVAR, L. G
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.11.1999
Subjects
Anatomy & physiology
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Calcium
Cardiology. Vascular system
Experimental diseases
Hormones
Kidneys
Medical sciences
Rodents
Hypertension
Molecular form
Rat
Enzyme
Rodentia
Cardiovascular disease
Gene expression
Kidney
Nitric-oxide synthase
Renin angiotensin system
Vertebrata
Mammalia
Calcium ion
Urinary system
Enzymatic activity
Animal
Oxidoreductases
Angiotensin II
Renal cortex
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Summary:We have previously demonstrated that nitric oxide (NO) exerts a greater modulatory influence on renal cortical blood flow in ANG II-infused hypertensive rats compared with normotensive rats. In the present study, we determined nitric oxide synthase (NOS) activities and protein levels in the renal cortex and medulla of normotensive and ANG II-infused hypertensive rats.
ISSN:1931-857X
1522-1466