Aquaporin-2 expression in primary cultured rat inner medullary collecting duct cells

Cultured renal epithelial cells rapidly downregulate expression of the vasopressin-regulated water channel aquaporin-2 (AQP-2). Our aim was to define conditions that favor maintenance of AQP-2 expression in vitro without genetic manipulation.

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Bibliographic Details
Published inAmerican journal of physiology. Renal physiology Vol. 44; no. 5; pp. F796 - F801
Main Authors MARIC, K, OKSCHE, A, ROSENTHAL, W
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Physiological Society 01.11.1998
Subjects
Biological and medical sciences
Cellular biology
Diabetes
Fundamental and applied biological sciences. Psychology
Gene expression
Genes
Kidneys
Molecular and cellular biology
Molecular genetics
Rodents
Endocrinopathy
Cell culture
Rat
Diabetes insipidus
Rodentia
Cyclic AMP
Gene expression
Neuropeptide
In vitro
Kidney
Vasopressin
Northern blotting
Medium enrichment
Vertebrata
Regulation(control)
Mammalia
Urinary system
Collecting duct
Immunofluorescence
Aquaporin
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Summary:Cultured renal epithelial cells rapidly downregulate expression of the vasopressin-regulated water channel aquaporin-2 (AQP-2). Our aim was to define conditions that favor maintenance of AQP-2 expression in vitro without genetic manipulation.
ISSN:1931-857X
1522-1466