Analysis of Risk Factors Affecting the Chemotherapy-related Infections in Patients with ALL

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 27; no. 6; p. 1825
• Main Authors: He, Yu-Zhuo, Guo, Xue-Jun, Lin, Xiao-Yan, Zhu, Hong-Bin
• Format: Journal Article
• Language: Chinese
• Published: China 01.12.2019
• Subjects: Drug Resistance, Bacterial; Gram-Negative Bacteria; Humans; Infections; Microbial Sensitivity Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Risk Factors
• ISSN: 1009-2137
• DOI: 10.19746/j.cnki.issn.1009-2137.2019.06.019

To analyze the risk factors affecting the chemotherapy-related infections in patients with acute lympho-blastic leukemia (ALL). The clinical data of 102 patients with ALL from January 2014 to December 2018 were collected and retrospectively studies. The risk factors of chemotherapy-related infections were analyzed by univa-riate and multivariate logistic regression. A total of 386 courses of chemotherapy were completed, out of which the infection occurred in 201 course, with the infection rate of 52.07%, identified infection number was 215 case-times, including perianal infection of 13.95% (30/215), oral infection of 13.49% (29/215), blood flow infection of 1721% (37/215), lower respiratory tract infection of 37.21% (80/215), urinary infection of 3.26% (7/215), skin infection of 3.72% (8/215), digestive and intra abdominal infection of 9.30% (20/215), and other infections of 1.86 (4/215). Totally 88 strains of pathogenic bacteria were detected, including 29 Gram-positive bacteria (32.95%), 52 Gram-negative b