Antibacterial therapy of community-acquired pneumonia in a hospital: real clinical practice

The aim of the study was to analyse results of antibiotic treatment of community-acquired pneumonia in the pulmonological department of a multidisciplinary hospital and to estimate its conformity with the national guidelines. We undertook retrospective analysis of 110 case histories and prescription...

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Bibliographic Details
Published inKlinicheskaia meditsina Vol. 90; no. 12; p. 21
Main Authors Sinopal'nikov, A I, Astaf'ev, A V, Styrt, E A
Format Journal Article
LanguageRussian
Published Russia (Federation) 2012
Subjects
Anti-Bacterial Agents - administration & dosage
Community-Acquired Infections - drug therapy
Dose-Response Relationship, Drug
Female
Humans
Inpatients
Male
Middle Aged
Pneumonia - drug therapy
Retrospective Studies
Treatment Outcome
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Summary:The aim of the study was to analyse results of antibiotic treatment of community-acquired pneumonia in the pulmonological department of a multidisciplinary hospital and to estimate its conformity with the national guidelines. We undertook retrospective analysis of 110 case histories and prescriptions to patients with pneumonia (age median 58.5 yr, men 58%). Severe community-acquired occurred in 9% of the cases. Antibacterial therapy at the pre-hospitalization stage was given to 1/3 patients. After hospitalization, the starting therapy most frequently included cefazoline (32.7%), ampicillin (21.8%) or cefotaxim (14.5%). Combinations of cefazoline + ciprofloxacin was used in 7.3%, ampicillin + ciprofloxacin in 4.5%, cefotaxim + ciprofloxacin in 2.7% of the cases. Correction of first-line therapy was needed in 55.4% of the cases because of its inefficiency. Median of duration of antibiotic therapy was 17 days, 2.7% of the cases were switched from intravenous to oral treatment.
ISSN:0023-2149