Application value of heparin-binding protein in early diagnosis of severe infection in silicosis patients

• Published in: Zhōnghuá yùfáng-yīxué zázhì Vol. 53; no. 8; p. 835
• Main Authors: Zhang, X T, Han, W
• Format: Journal Article
• Language: Chinese
• Published: China 06.08.2019
• Subjects: Antimicrobial Cationic Peptides - blood; Blood Proteins; C-Reactive Protein - analysis; Carrier Proteins - blood; Early Diagnosis; Humans; Leukocyte Count; Procalcitonin - blood; ROC Curve; Sepsis - complications; Sepsis - diagnosis; Silicosis - blood; Silicosis - complications; Infection; Diagnostic tests, routine; Heparin-binding protein; Silicosis
• ISSN: 0253-9624
• DOI: 10.3760/cma.j.issn.0253-9624.2019.08.007

To explore the value of heparin-binding protein (HBP) in early diagnosis of severe infection in silicosis patients. From January 2017 to June 2018, fifty silicosis patients with severe infection and fity without infection were recruited in the Second Affiliated Hospital of Xuzhou Medical University. In the severe infection group, the time of patients diagnosed with severe infection was set as the reference point for time. Blood samples were selected from the hospital inspection system sample library at the time of 24, 48, and 72 hours prior to the reference point. In the non-infection group, blood samples were selected within 24 hours of admission. The blood samples were tested for the levels of HBP, C-reactive protein (CRP), procalcitonin (PCT), and white blood cell (WBC) count. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve, sensitivity, specificity and Youden index (YI) were used to evaluate the diagnostic efficacy of each indicator. The HBP levels at 72, 48, 24, and 0